A covariate-adjusted response-adaptive allocation in clinical trials for a general class of responses

Uttam Bandyopadhyay; Rahul Bhattacharya

doi:10.1002/sim.5900

A covariate-adjusted response-adaptive allocation in clinical trials for a general class of responses

Stat Med. 2013 Dec 20;32(29):5053-61. doi: 10.1002/sim.5900. Epub 2013 Jul 19.

Authors

Uttam Bandyopadhyay¹, Rahul Bhattacharya

Affiliation

¹ Department of Statistics, University of Calcutta, Kolkata, India.

PMID: 23873514
DOI: 10.1002/sim.5900

Abstract

A class of covariate-adjusted adaptive allocation procedures is developed for a general class of responses with an aim to satisfy relevant clinical requirements. Some exact and asymptotic properties of the procedures, proposed and a reasonable competitor, are studied and compared under the presence of treatment-covariate interaction.

Keywords: covariate-adjusted allocation; ethics; response-adaptive design.

MeSH terms

Adult
Age Factors
Clinical Trials as Topic / methods*
Data Interpretation, Statistical*
Humans
Hypertension / diet therapy
Middle Aged
Research Design*