Abstract
Two rare new chiratane-type triterpenoids, kouitchenoids A and B (1, 2), together with oleanolic acid (3) and ursolic acid (4), were isolated from ethanol extract of Swertia kouitchensis. The new structures were determined by the analysis of MS and NMR data. In addition, compounds 1-4 showed moderate inhibitory activity against the α-glucosidase (with IC₅₀ values ranging from 1,812 to 2,027 μM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Glycoside Hydrolase Inhibitors*
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Plant Extracts / chemistry*
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Saccharomyces cerevisiae / enzymology
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Swertia / chemistry*
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Ursolic Acid
Substances
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Glycoside Hydrolase Inhibitors
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Plant Extracts
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Triterpenes
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Oleanolic Acid