Merging organocatalysis with transition metal catalysis and using O2 as the oxidant for enantioselective C-H functionalization of aldehydes

Chem Commun (Camb). 2013 Sep 4;49(68):7555-7. doi: 10.1039/c3cc44214d.

Abstract

A new catalytic Saegusa oxidation-Michael addition cascade reaction has been developed for the enantioselective β-functionalization of aldehydes. The feature of this research is the combination of organocatalysis and transition-metal catalysis for the asymmetric C-H functionalization which remains an underdeveloped research topic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Catalysis
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Oxidants / chemistry*
  • Oxygen / chemistry*
  • Palladium / chemistry*
  • Stereoisomerism

Substances

  • Aldehydes
  • Organometallic Compounds
  • Oxidants
  • Palladium
  • Oxygen