Objective: To evaluate the effect of aqueous leaf extract of Guiera senegalensis (G. senegalensis) on gastric mucosal damage using different ulcer models.
Methods: Considering the above claims, the present study was undertaken to validate the gastroprotective potential of the aqueous leaf extract of this plant against ethanol, water immersion and Aspirin induced ulcer models.
Results: The leaf extract (50, 100 and 200 mg/kg, p.o.) significantly (P<0.05) decreased the ulcer index in all assays used.
Conclusions: The results obtained, provide strong evidence of antiulcer activity of the leaf extract of G. senegalensis and support the traditional uses of the plant for the treatment of ulcer.
Keywords: Aqueous extract; Aspirin; Ethanol; Guiera senegalensis; Stress induced gastric ulcers.
Copyright © 2013 Hainan Medical College. Published by Elsevier B.V. All rights reserved.