Aging: seeking mitonuclear balance

Cell. 2013 Jul 18;154(2):271-3. doi: 10.1016/j.cell.2013.06.046.

Abstract

Metabolic imbalances accompany the aging process in many organisms, and signaling mechanisms that allay or prevent these imbalances can extend lifespan. Two recent studies by Auwerx and colleagues, including one in this issue, identify a conserved signaling network centered on mitochondrial stress responses that promotes longevity in response to changes in mitochondrial translation and NAD(+) metabolism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Forkhead Transcription Factors / metabolism*
  • Longevity*
  • Mitochondria / metabolism*
  • NAD / metabolism*
  • Signal Transduction*
  • Unfolded Protein Response*

Substances

  • Forkhead Transcription Factors
  • NAD