Born equal: dual safeguards for daughter cell size symmetry

Cell. 2013 Jul 18;154(2):269-71. doi: 10.1016/j.cell.2013.06.035.

Abstract

Development and homeostasis require repeated symmetric cell divisions, which in turn depend on a centered mitotic spindle. In this issue, Kiyomitsu and Cheeseman uncover two mechanisms that ensure correct spindle positioning in anaphase: cortical dynein for pulling the spindle to the cell center and asymmetric membrane elongation that adjusts the position of the cell center to the cleavage plane.

Publication types

  • Comment

MeSH terms

  • Anaphase*
  • Animals
  • Cell Membrane / metabolism*
  • Dyneins / metabolism*
  • Humans
  • Spindle Apparatus / metabolism*

Substances

  • Dyneins