Abstract
A new protopanaxadiol-type ginsenoside, 6-O-β-d-glucopyranosyl-20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol-3-one (1), along with three known compounds, was isolated from the roots of Panax notoginseng. Their structures were determined based on some pieces of spectroscopic and chemical evidence. Compound 1 exhibited cytotoxic activity against five human cancer cell lines, with IC50 values ranging from 5.4 to 8.6 μg/ml.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Ginsenosides / chemistry
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Ginsenosides / isolation & purification*
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Ginsenosides / pharmacology
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Panax notoginseng / chemistry*
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Plant Roots / chemistry
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Sapogenins / chemistry
Substances
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6-O-beta-D-glucopyranosyl-20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol-3-one
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Ginsenosides
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Sapogenins
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ginsenoside M1
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protopanaxadiol