Trick to treat: tricking the thymus to treat cancer

Blood. 2013 Jul 18;122(3):304-6. doi: 10.1182/blood-2013-06-504100.

Abstract

In this issue of Blood, Schmitt et al address the biology and safety of T cells engineered to express T-cell receptor (TCR) variants endowed with enhanced affinity for tumor-associated antigens.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, Neoplasm / immunology*
  • Autoantigens / immunology*
  • Genetic Therapy*
  • Humans
  • Receptors, Antigen, T-Cell / immunology*
  • Thymus Gland / immunology*

Substances

  • Antigens, Neoplasm
  • Autoantigens
  • Receptors, Antigen, T-Cell