Atypical cadherin negotiates a turn

Dev Cell. 2013 Jul 15;26(1):1-2. doi: 10.1016/j.devcel.2013.06.024.

Abstract

Planar cell polarity (PCP) signaling is involved in many polarized cell behaviors. In this issue of Developmental Cell, Tatin et al. (2013) show that the atypical cadherin Celsr1 is transiently localized to cellular protrusions in lymphatic endothelial cells and acts to orient valve-forming cells perpendicular to the vessel axis.

Publication types

  • Comment

MeSH terms

  • Adherens Junctions / metabolism*
  • Animals
  • Cell Polarity*
  • Female
  • Humans
  • Lymphatic Vessels / metabolism*
  • Morphogenesis*
  • Receptors, G-Protein-Coupled / metabolism*

Substances

  • Celsr1 protein, mouse
  • Receptors, G-Protein-Coupled