Hydrogel-based microactuators that enable remote-controlled locomotion and fast Pb(2+)-response for micromanipulation in Pb(2+)-polluted microenvironment have been fabricated from quadruple-component double emulsions. The microactuators are Pb(2+)-responsive poly(N-isopropylacrylamide-co-benzo-18-crown-6-acrylamide) microgels, each with an eccentric magnetic core for magnetic manipulation and a hollow cavity for fast Pb(2+)-response. Micromanipulation of the microactuators is demonstrated by using them for preventing Pb(2+)-leakage from microchannel. The microactuators can be remotely and precisely transported to the Pb(2+)-leaking site under magnetic guide, and then clog the microchannel with Pb(2+)-responsive volume swelling to prevent flowing out of Pb(2+)-contaminated solution. The proposed microactuator structure provides a potential and novel model for developing multifunctional actuators and sensors, biomimetic soft microrobots, microelectro-mechanical systems and drug delivery systems.