All-catalytic route to trisubstituted allenes: The first examples of catalytic enantioselective allylic substitution reactions that involve alkyne-based nucleophiles and lead to products having tertiary stereogenic centers are followed by an exceptionally stereospecific amine-catalyzed isomerization to trisubstituted allenes (see picture; NHC = N-heterocyclic carbene).
Keywords: Brønsted bases; N-heterocyclic carbenes; alkynylaluminum reagents; allenes; copper.
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