Abstract
A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetates / chemical synthesis*
-
Acetates / chemistry*
-
Aldehydes / chemistry*
-
Decarboxylation
-
Models, Molecular
-
Molecular Structure
-
Organophosphates / chemistry*
-
Organophosphorus Compounds / chemical synthesis*
-
Organophosphorus Compounds / chemistry*
Substances
-
Acetates
-
Aldehydes
-
Organophosphates
-
Organophosphorus Compounds
-
chlorodifluoroacetic acid
-
triphenyl phosphate