Abstract
A new strategy that centers on the incorporation of stimuli-responsive cleavable linkages in dual or multiple locations as in both micellar cores and at polymer/solution interfaces leading to synergistically enhanced release of encapsulated anticancer drugs in cancer cells.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology*
-
Cell Proliferation / drug effects
-
Cell Survival / drug effects
-
Dose-Response Relationship, Drug
-
Doxorubicin / chemistry
-
Doxorubicin / pharmacology*
-
Drug Carriers / chemistry*
-
Drug Screening Assays, Antitumor
-
HeLa Cells
-
Humans
-
Micelles
-
Molecular Structure
-
Nanostructures / chemistry*
-
Particle Size
-
Polymers / chemistry*
-
Structure-Activity Relationship
-
Surface Properties
Substances
-
Antineoplastic Agents
-
Drug Carriers
-
Micelles
-
Polymers
-
Doxorubicin