A dual location stimuli-responsive degradation strategy of block copolymer nanocarriers for accelerated release

Chem Commun (Camb). 2013 Sep 4;49(68):7534-6. doi: 10.1039/c3cc44200d.

Abstract

A new strategy that centers on the incorporation of stimuli-responsive cleavable linkages in dual or multiple locations as in both micellar cores and at polymer/solution interfaces leading to synergistically enhanced release of encapsulated anticancer drugs in cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology*
  • Drug Carriers / chemistry*
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • Micelles
  • Molecular Structure
  • Nanostructures / chemistry*
  • Particle Size
  • Polymers / chemistry*
  • Structure-Activity Relationship
  • Surface Properties

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Micelles
  • Polymers
  • Doxorubicin