How can we achieve relief of bowel and abdominal symptoms for patients with irritable bowel syndrome with constipation?

Expert Rev Gastroenterol Hepatol. 2013 Jul;7(5 Suppl 1):21-6. doi: 10.1586/17474124.2013.820046.

Abstract

Current interventions for irritable bowel syndrome with constipation tend to target single symptoms of the disorder, with multiple symptom relief only achieved through the use of combinations of therapies. Hence, there remains an unmet need for well-tolerated and effective treatments for irritable bowel syndrome with constipation that target abdominal symptoms, including abdominal pain and bowel symptoms.

Publication types

  • Review

MeSH terms

  • Abdominal Pain / diagnosis
  • Abdominal Pain / drug therapy*
  • Abdominal Pain / etiology
  • Abdominal Pain / physiopathology
  • Constipation / diagnosis
  • Constipation / drug therapy*
  • Constipation / etiology
  • Constipation / physiopathology
  • Defecation / drug effects*
  • Gastrointestinal Agents / adverse effects
  • Gastrointestinal Agents / therapeutic use*
  • Humans
  • Irritable Bowel Syndrome / complications
  • Irritable Bowel Syndrome / diagnosis
  • Irritable Bowel Syndrome / drug therapy*
  • Irritable Bowel Syndrome / physiopathology
  • Peptides / adverse effects
  • Peptides / therapeutic use*
  • Treatment Outcome

Substances

  • Gastrointestinal Agents
  • Peptides
  • linaclotide