Abstract
In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Albendazole / analogs & derivatives
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Albendazole / pharmacology*
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Animals
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Anthelmintics / pharmacology*
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Antibodies, Protozoan / immunology
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Gene Expression Regulation
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Giardia / drug effects*
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Giardia / growth & development
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Giardia / immunology
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Giardia / ultrastructure
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Mice
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Mice, Inbred BALB C
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Microscopy, Confocal
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Microscopy, Electron, Scanning
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Protozoan Proteins / immunology
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Protozoan Proteins / metabolism
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Rats
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Rats, Wistar
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Recombinant Proteins
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Trophozoites / drug effects
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Trophozoites / growth & development
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Trophozoites / immunology
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Trophozoites / ultrastructure
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Tubulin / metabolism
Substances
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Anthelmintics
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Antibodies, Protozoan
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CWP1 protein, Giardia lamblia
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Protozoan Proteins
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Recombinant Proteins
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Tubulin
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Albendazole