This study surveyed pediatric occupational therapy practitioners regarding their knowledge and perceptions about the chronic respiratory diseases (CRDs) asthma and cystic fibrosis which affect the functioning and quality of life for millions of children. Surveys were mailed to 250 members of the Ohio Occupational Therapy Association's pediatric member support group. Though 104 occupational therapy practitioners returned completed surveys, only the 82 who were currently practicing in pediatric settings were included in analysis. Respondents scored an average of 77% (SD = 10%) on a test of knowledge about asthma and cystic fibrosis. Respondents demonstrated several misperceptions about of the effects of these diseases on everyday life. A large majority (91%) endorsed one or more roles for occupational therapy with children with chronic respiratory diseases. Respondents indicated that confusion about the role of occupational therapy is a barrier to practice with children with CRDs. The results may prompt educational curricula to make adjustments, while continuing education courses may expand in addressing CRDs.