Cytotoxic cardenolides from the root bark of Calotropis gigantea

Hanyun You; Min Lei; Weibin Song; Hu Chen; Yuhui Meng; Dean Guo; Xuan Liu; Lihong Hu

doi:10.1016/j.steroids.2013.06.002

Cytotoxic cardenolides from the root bark of Calotropis gigantea

Steroids. 2013 Oct;78(10):1029-34. doi: 10.1016/j.steroids.2013.06.002. Epub 2013 Jul 12.

Authors

Hanyun You¹, Min Lei, Weibin Song, Hu Chen, Yuhui Meng, Dean Guo, Xuan Liu, Lihong Hu

Affiliation

¹ School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China.

PMID: 23851141
DOI: 10.1016/j.steroids.2013.06.002

Abstract

Six new cardenolides (1, 2 and 11-14), along with ten known ones, were isolated from the root bark of Calotropis gigantea. The structural determination was accomplished by the 1D- and 2D-NMR spectrum as well as ESIMS analysis. The isolated compounds were evaluated for their in vitro growth inhibitory activity against human A549 and Hela cell lines. The results suggested that some of these cardenolides (compounds 1, 6, and 8) displayed potent cytotoxicities.

Keywords: Antitumor agent; Asclepiadaceae; Calotropis gigantea; Cardenolide; Cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Calotropis / chemistry*
Cardenolides / chemistry
Cardenolides / isolation & purification
Cardenolides / pharmacology*
Cell Survival / drug effects
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Bark / chemistry*
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / pharmacology*
Plant Roots / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Cardenolides
Plant Extracts