Synthesis and biological evaluation of 2-arylamino-5- (3'-indolyl)-1,3,4-oxadiazoles as potent cytotoxic agents

ChemMedChem. 2013 Sep;8(9):1468-74. doi: 10.1002/cmdc.201300221. Epub 2013 Jul 11.
No abstract available

Keywords: 1,3,4-oxadiazoles; anticancer activity; apoptosis; cytotoxic agents; indoles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / toxicity
  • Apoptosis / drug effects
  • Cell Line
  • Cell Proliferation / drug effects
  • HeLa Cells
  • Humans
  • Indoles / chemistry
  • MCF-7 Cells
  • Microscopy, Fluorescence
  • Oxadiazoles / chemical synthesis
  • Oxadiazoles / chemistry*
  • Oxadiazoles / toxicity
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Indoles
  • Oxadiazoles
  • indole