Inhibition of the renin-angiotensin system (RAS) has been shown to have beneficial effects in cardiovascular disease prognosis and therapy.Discovery of (pro)renin receptor [(P)RR] revealed that (P)RR upon binding to both renin or prorenin in their proenzyme inactive form made them enzymatically active, thus aiding the catalytic conversion of angiotensinogen (AGT) to angiotensin (Ang) I. This binding also transduces intracellular signal to the nucleus via various pathways. Our recent research elucidated the physiological roles of (P)RR in cell life, wherein it acts as an essential accessory protein of vacuolar H(+)-ATPase (V-ATPase) as well as an adaptor protein of Wnt signaling. The present review provides insights into a novel approach to cardiovascular diseases, which will open the gates to new therapeutic approaches for treating cardiovascular diseases.