Novel method for early signs of clinical shock detection by monitoring blood capillary/vessel spatial pattern

Abstract

The ability to monitor capillary/vessel spatial patterns and local blood volume fractions is critical in clinical shock detection and its prevention in Intensive Care Units (ICU). Although the causes of shock might be different, the basic abnormalities in pathophysiological changes are the same. To detect these changes, we have developed a novel method based on both spectrally and spatially resolved diffuse reflectance spectra. The preliminary study has shown that this method can monitor the spatial distribution of capillary/vessel spatial patterns through local blood volume fractions of reduced hemoglobin and oxyhemoglobin. This method can be used as a real-time and non-invasive tool for the monitoring of shock development and feedback on the therapeutic intervention.

Keywords: Clinical shock; epithelium capillary/vessel spatial pattern; oxygen saturation (SO2); oxyhemoglobin (HbO2); reduced hemoglobin (RHb); skin tissue phantom; spatially resolved diffuse reflectance.