Risk factors of liver failure after right-sided hepatectomy

Abstract

Background: To prevent hepatic failure after major hepatectomy, it is important to assess preoperative factors related to liver failure.

Methods: We examined 80 patients who underwent right-sided hepatectomy. Hyperbilirubinemia, uncontrolled ascites, and prolonged postoperative hospital stay were defined as liver failure after hepatectomy, and these 3 factors were evaluated in relation to clinicopathological and surgical factors.

Results: In the 80 patients, hyperbilirubinemia was observed in 10 (12.7%) patients, uncontrolled ascites in 18 (22.5%) patients, and prolonged hospital stay after surgery in 39 (48.8%) patients. Multivariate analyses identified platelet count as a risk factor of hyperbilirubinemia, uncontrolled ascites, and prolonged postoperative hospital stay, and the ratio of remnant liver volume to body surface area (RLV/BSA ratio) as an additional risk factor of hyperbilirubinemia and prolonged postoperative hospital stay.

Conclusions: Platelet count and RLV/BSA ratio are useful risk factors for prediction of liver failure after right-sided hepatectomy.

Keywords: Hepatectomy; Liver failure; Major hepatectomy; Morbidity; Platelet count; Volumetry.