Abstract
Nanocomposite to achieve ultrafast immunoassay: a new synergistically integrated nanocomposite consisting of magnetic and platinum nanoparticles, simultaneously entrapped in mesoporous carbon, is developed as a promising enzyme mimetic candidate to achieve ultrafast colorimetric immunoassays. Using new assay system, clinically important target molecules, such as human epidermal growth factor receptor 2 (HER2) and diarrhea-causing rotavirus, can be detected in only 3 min at room temperature with high specificity and sensitivity.
Keywords:
enzyme mimetics; immunoassays; magnetic nanoparticles; mesoporous materials; nanocomposite.
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antibodies / immunology
-
Biocompatible Materials / chemistry
-
Biocompatible Materials / metabolism
-
Breast Neoplasms / metabolism
-
Breast Neoplasms / pathology
-
Carbon / chemistry
-
Colorimetry*
-
Female
-
Ferrosoferric Oxide / chemistry
-
Humans
-
Immunoassay / instrumentation
-
Immunoassay / methods*
-
MCF-7 Cells
-
Magnetite Nanoparticles / chemistry
-
Metal Nanoparticles / chemistry
-
Nanocomposites / chemistry*
-
Platinum / chemistry
-
Porosity
-
Receptor, ErbB-2 / analysis*
-
Receptor, ErbB-2 / immunology
-
Rotavirus / immunology
-
Rotavirus / isolation & purification*
-
Temperature
-
Time Factors
Substances
-
Antibodies
-
Biocompatible Materials
-
Magnetite Nanoparticles
-
Platinum
-
Carbon
-
ERBB2 protein, human
-
Receptor, ErbB-2
-
Ferrosoferric Oxide