A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells

Chem Commun (Camb). 2013 Aug 18;49(64):7141-3. doi: 10.1039/c3cc42653j.

Abstract

We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug is able to monitor drug delivery and cellular imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / metabolism
  • Drug Delivery Systems*
  • Drug Monitoring
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Gemcitabine
  • Humans
  • Microscopy, Confocal
  • Molecular Structure
  • Prodrugs / chemical synthesis*
  • Prodrugs / chemistry*

Substances

  • Fluorescent Dyes
  • Prodrugs
  • Deoxycytidine
  • Gemcitabine