Abstract
We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug is able to monitor drug delivery and cellular imaging.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cell Line, Tumor
-
Deoxycytidine / analogs & derivatives*
-
Deoxycytidine / metabolism
-
Drug Delivery Systems*
-
Drug Monitoring
-
Fluorescent Dyes / chemical synthesis*
-
Fluorescent Dyes / chemistry
-
Gemcitabine
-
Humans
-
Microscopy, Confocal
-
Molecular Structure
-
Prodrugs / chemical synthesis*
-
Prodrugs / chemistry*
Substances
-
Fluorescent Dyes
-
Prodrugs
-
Deoxycytidine
-
Gemcitabine