Emerging concepts on the role of exosomes in lipid metabolic diseases

Abstract

Dysregulation of lipid metabolism involves cellular communication mediated by cell contacts or exchange of bioactive lipids bound to soluble carriers or to lipoproteins. An increasing field is that of cellular communication mediated by nanovesicles called exosomes. Those vesicles are released from an internal compartment of viable cells, circulate in all biological fluids and can transfer material from cell-to-cells. Involvement of exosome trafficking in the transcellular metabolism of eicosanoids and cholesterol-related diseases including cancer is developed hereafter.

Keywords: CD36; Cancer; Cholesterol epoxyde hydrolase (CHEH); Docosahexaenoic acid (DHA); Eicosanoids; Phospholipases; Tamoxifen.