Lessons from lipids in the fight against influenza

Cell. 2013 Jul 3;154(1):22-3. doi: 10.1016/j.cell.2013.06.024.

Abstract

Influenza is a leading cause of morbidity and mortality worldwide, with vaccines and antiviral drugs having limited efficacy thus far. Two recent studies in Cell apply lipidomics approaches to identify bioactive lipid mediators influencing host inflammation, viral replication, and disease progression.

Publication types

  • Comment

MeSH terms

  • Active Transport, Cell Nucleus*
  • Animals
  • Docosahexaenoic Acids / immunology*
  • Eicosanoids / isolation & purification*
  • Fatty Acids, Unsaturated / isolation & purification*
  • Humans
  • Influenza A Virus, H1N1 Subtype / physiology*
  • Influenza A Virus, H3N2 Subtype / physiology*
  • Influenza A Virus, H5N1 Subtype / physiology*
  • Influenza, Human / immunology*
  • Lipids / analysis*
  • Orthomyxoviridae Infections / immunology*
  • Virus Replication*

Substances

  • Eicosanoids
  • Fatty Acids, Unsaturated
  • Lipids
  • hydroxyoctadecadienoic acid
  • Docosahexaenoic Acids