Abstract
Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from the aerial parts of Schaefferia argentinensis Speg. Their structures were determined by a combination of 1D and 2D NMR and MS techniques. The in vitro antiproliferative activity of the major sesquiterpenes was examined in T47D, MCF7, and MDA-MB231 human cancer cell lines, but was found to be marginal.
Keywords:
Antiproliferative activity; Celastraceae; Dihydro-β-agarofuran sesquiterpene; Phytochemistry; Schaefferia argentinensis.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Celastraceae / chemistry*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Humans
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MCF-7 Cells
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Magnetic Resonance Spectroscopy
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Mass Spectrometry / methods
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Molecular Structure
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Plant Components, Aerial / chemistry*
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Sesquiterpenes
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dihydroagarofuran