Agarofuran sesquiterpenes from Schaefferia argentinensis

Phytochemistry. 2013 Oct:94:260-7. doi: 10.1016/j.phytochem.2013.06.003. Epub 2013 Jul 1.

Abstract

Sixteen dihydro-β-agarofuran sesquiterpenes were isolated from the aerial parts of Schaefferia argentinensis Speg. Their structures were determined by a combination of 1D and 2D NMR and MS techniques. The in vitro antiproliferative activity of the major sesquiterpenes was examined in T47D, MCF7, and MDA-MB231 human cancer cell lines, but was found to be marginal.

Keywords: Antiproliferative activity; Celastraceae; Dihydro-β-agarofuran sesquiterpene; Phytochemistry; Schaefferia argentinensis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Celastraceae / chemistry*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Humans
  • MCF-7 Cells
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry / methods
  • Molecular Structure
  • Plant Components, Aerial / chemistry*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Sesquiterpenes
  • dihydroagarofuran