Restrictive pulmonary deficit is associated with inflammation in sub-optimally controlled obese diabetics

Lexley M Pinto Pereira; Terence A R Seemungal; Surujpal Teelucksingh; B Shivananda Nayak

doi:10.3978/j.issn.2072-1439.2012.07.06

Restrictive pulmonary deficit is associated with inflammation in sub-optimally controlled obese diabetics

J Thorac Dis. 2013 Jun;5(3):289-97. doi: 10.3978/j.issn.2072-1439.2012.07.06.

Authors

Lexley M Pinto Pereira¹, Terence A R Seemungal, Surujpal Teelucksingh, B Shivananda Nayak

Affiliation

¹ Departments of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago, West Indies.

PMID: 23825761
PMCID: PMC3698295
DOI: 10.3978/j.issn.2072-1439.2012.07.06

Abstract

Caribbean data linking inflammation, pulmonary dysfunction and diabetes is unavailable. Spirometry, acanthosis nigricans, hs-CRP were assessed in 109 type 2 diabetics (43% males) mean age=55.6 years, BMI=29.29 kg/m(2), waist circumference=103.86 cm. Residual FEV1/FVC increased with age (P=0.005), BMI (P=0.011) and waist circumference (P=0.003). Residual FVC related inversely to hs-CRP (-0.178), P<0.06) systolic (-0.028, P<0.031), diastolic (-0.247, P<0.010) pressure and weight (-0.25, P<0.009). Residual FEV1 related inversely to diastolic pressure (-0.219, P<0.023), hs-CRP (-0.234, P<0.015), acanthosis nigricans (-0.029, P<0.029). HbA1C and residual FEV1 predict high hs-CRP (P=0.011, P=0.046). Low FVC with inflammation presents in poorly controlled obese diabetics.

Keywords: Impaired pulmonary function; diabetes mellitus type 2; obesity; systemic inflammation.