Abstract
Two new phenolic glycosides, named gnaphaffine A and B (compounds 1 and 2), were isolated from Gnaphalium affine. together with six known compounds, including caffeic acid (3), everlastoside L (4), isorhamnetin-7-O-β-D-glucopyranoside (5), quercetin- 3-O-β-D-glucopyranoside (6), scutellarein-7-O-β-D-glucoside (7) and api-genin-7-O-β-D- glucopyranoside (8). Their structures were elucidated by spectroscopic methods, including ESI-MS and 2D NMR spectroscopy (HMQC and HMBC). All compounds were evaluated for their anti-complementary activity on the classical pathway of the complement system in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Complement Inactivating Agents / chemistry
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Complement Inactivating Agents / pharmacology*
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Complement System Proteins / drug effects*
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Glycosides / analysis
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Gnaphalium / metabolism*
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Medicine, Chinese Traditional
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Phenols / analysis
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Phenols / chemistry
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Phenols / pharmacology*
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Plant Preparations / analysis
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Plant Preparations / chemistry
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Plant Preparations / pharmacology
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Spectrometry, Mass, Electrospray Ionization
Substances
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Complement Inactivating Agents
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Glycosides
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Phenols
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Plant Preparations
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Complement System Proteins