The economic crisis, as well as the need to improve patient safety, enhance healthcare services and reduce medical costs made Greek payers to support the implementation and usage of a national electronic prescribing system. The purpose of this paper is to evaluate physicians' attitudes towards e-Prescribing for suggesting improvements. Despite the fact that the physicians were generally satisfied with the e-prescribing system, the benefits of its use were not realized. Moreover, the authors identified key barriers, such as (1) system's unavailability, (2) time to adjust and adapt to e-prescribing, (3) change management issues, (4) lack of training, (5) Information Technology (IT) requirements and (6) medical coding limitations.