Abstract
Two new naphthaline glucosides, 2-hydroxy-3-methoxy-8-methyl-1-O-β-d-glucopyranosylnaphthaline (1) and 1-hydroxy-3-methoxy-8-methyl-2-O-β-d-glucopyranosylnaphthaline (2), together with one new isocoumarin glucoside, 3-(3,3-dichloro-2-hydroxylpropyl)-6-methoxy-8-O-β-d-glucopyranosyl-1H-isochromen-1-one (3), were isolated from a cold-adapted fungal strain Mucor sp. (No. XJ07027-5). Their structures were characterized by detailed analyses of IR, MS, 1D- and 2D-NMR spectra. Among them, 2 showed moderate cytotoxic activity against five tumor cells (A-549, HL-60, MCF-7, SMMC-7721, and SW480).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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China
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Cold Temperature
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Drug Screening Assays, Antitumor
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Female
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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HL-60 Cells
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Humans
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Isocoumarins / chemistry
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Isocoumarins / isolation & purification*
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Isocoumarins / pharmacology
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MCF-7 Cells
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Molecular Structure
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Mucor / chemistry*
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Stereoisomerism
Substances
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1-hydroxy-3-methoxy-8-methyl-2-O-beta-D-glucopyranosylnaphthaline
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2-hydroxy-3-methoxy-8-methyl-1-O-beta-D-glucopyranosylnaphthaline
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3-(3,3-dichloro-2-hydroxylpropyl)-6-methoxy-8-O-beta-D-glucopyranosyl-1H-isochromen-1-one
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Antineoplastic Agents
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Glucosides
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Isocoumarins
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Naphthalenes