Abstract
It was demonstrated in in vivo and in vitro experiments that interleukin-2, obtained by cultivation of donor lymphocytes and purified by gel filtration, induces the production of mouse and human killer lymphocytes possessing high cytolytic activity against tumor cells. Interleukin-2 does not cause irreversible changes of the physiological and morphologic indices of vital activity in mice.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Antineoplastic Agents*
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Cytotoxicity Tests, Immunologic / methods
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Drug Screening Assays, Antitumor
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Female
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Humans
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Interleukin-2 / isolation & purification
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Interleukin-2 / pharmacology
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Interleukin-2 / therapeutic use*
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Interleukin-2 / toxicity
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Killer Cells, Lymphokine-Activated / drug effects
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Killer Cells, Lymphokine-Activated / immunology
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Leukemia P388 / drug therapy
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Leukemia P388 / immunology
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Lymphocytes / drug effects
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Lymphocytes / immunology
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Mice
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Mice, Inbred BALB C
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Mice, Inbred DBA
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Time Factors
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Tumor Cells, Cultured / drug effects
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Tumor Cells, Cultured / immunology
Substances
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Antineoplastic Agents
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Interleukin-2