Ring chromosome with deletion 7q in acute myeloid leukaemia

BMJ Case Rep. 2013 Jun 21:2013:bcr2013009942. doi: 10.1136/bcr-2013-009942.

Abstract

Cytogenetic abnormalities can be detected in approximately 50-60% of newly diagnosed adult patients with acute myeloid leukaemia (AML). Monosomy of the chromosome 7 (-7) and deletion of the long arm of the chromosome 7 (7q-) are considered as high cytogenetic-risk AML with a poor prognosis. These abnormalities can occur, as a single chromosomal aberration, in approximately 8% of newly diagnosed AML. We report an elderly patient with AML who had deletion 7q (7q-) along with ring chromosome, which was demonstrated in conventional cytogenetics and fluoresecent in-situ hybridisation techniques.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 7*
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Ring Chromosomes*