Bone morphological abnormalities, such as acetabular dysplasia, femoroacetabular impingement (FAI) , and knee varus deformity, are causes of osteoarthritis (OA) . These deformities have complex three-dimensional characteristics, and an accurate image assessment is not always easy. In recent years, statistical shape models (SSM) have been applied to analyzing variations of bone morphology in OA. Bone microstructural changes in OA include bone sclerosis, subchondral cysts, and osteophytes. Recent studies show that various pathological changes in subchondral bone affect the onset and development of OA, becoming targets for new drugs. Quantitative methods to analyze the subchondral trabecular bone of OA patients using MDCT and 3TMRI are currently under development.