Triterpene saponins from Tabellae Clinopodii

Fitoterapia. 2013 Oct:90:14-9. doi: 10.1016/j.fitote.2013.06.014. Epub 2013 Jun 27.

Abstract

Three new triterpene saponins, named Clinoposaponin A, Clinoposaponin B, and Clinoposaponin C along with three known triterpene saponins were isolated from the Tabellae Clinopodii. The structures of these compounds were elucidated by means of various spectroscopic analyses. All of the isolated compounds were tested against Hela, HCT-8, AGS, and MCF-7 human cancer cell lines and showed moderate cytotoxic activities with IC₅₀ values between 4.1 and 19.7 μM.

Keywords: Clinopodium; Cytotoxic activities; Saponins; Tabellae Clinopodii.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • HeLa Cells
  • Humans
  • Lamiaceae / chemistry*
  • MCF-7 Cells
  • Molecular Structure
  • Neoplasms / drug therapy
  • Oleanolic Acid / analogs & derivatives*
  • Oleanolic Acid / chemistry
  • Oleanolic Acid / isolation & purification
  • Oleanolic Acid / pharmacology
  • Oleanolic Acid / therapeutic use
  • Phytotherapy
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Roots
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Saponins / therapeutic use

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Saponins
  • clinoposaponin I
  • Oleanolic Acid