The skeleton in the closet

Gene. 2013 Oct 1;528(1):7-11. doi: 10.1016/j.gene.2013.06.022. Epub 2013 Jun 25.

Abstract

The origins of fibrodysplasia ossificans progressiva (FOP) in human history are unknown but the condition has been well described since Freke's account in 1740. Important contributions by physicians and scientists in the past two and a half centuries have converged on the remarkable skeleton of Harry Eastlack at The Mutter Museum of The College of Physicians in Philadelphia.

Keywords: ACVR1/ALK2; BMP; FOP; Fibrodysplasia ossificans progressiva; activin A receptor, type I/activin receptor-like kinase 2; bone morphogenetic protein; fibrodysplasia ossificans progressiva.

Publication types

  • Biography
  • Historical Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Morphogenetic Protein Receptors, Type I / genetics
  • Bone and Bones / abnormalities*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Museums
  • Mutation, Missense
  • Myositis Ossificans / genetics
  • Myositis Ossificans / history*
  • Philadelphia
  • Skeleton*

Substances

  • Bone Morphogenetic Protein Receptors, Type I

Personal name as subject

  • Harry Eastlack