Abstract
Chemical and pharmacological information on cantharidin-based small molecules was analyzed. The review summarizes new facts about blister beetles' metabolites for the period 2006-2012. General synthetic approaches to cantharidin-based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.
Keywords:
Diels-Alder cycloaddition reactions; anticancer activity; blister beetles; cantharidin analogs; drug design and development; protein phosphatases inhibitory activity.
© 2013 John Wiley & Sons A/S.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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Antineoplastic Agents / toxicity
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology
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Bridged Bicyclo Compounds, Heterocyclic / therapeutic use
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Bridged Bicyclo Compounds, Heterocyclic / toxicity
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Cantharidin / analogs & derivatives*
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Cantharidin / pharmacology*
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Cantharidin / therapeutic use
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Cantharidin / toxicity
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Cell Survival / drug effects
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Coleoptera / chemistry
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Coleoptera / metabolism
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Enzyme Activation / drug effects
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Humans
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Neoplasms / drug therapy
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Phosphoprotein Phosphatases / antagonists & inhibitors
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Phosphoprotein Phosphatases / metabolism
Substances
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Antineoplastic Agents
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Bridged Bicyclo Compounds, Heterocyclic
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norcantharidin
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Phosphoprotein Phosphatases
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Cantharidin