The authors present immediate and five-year results of complex endovascular and surgical treatment of 8 patients with loco-regional rectal cancer. The immediate positive result was achieved by using the single-stage selective oily chemoembolization of the upper, middle and low rectal arteries. This leads to the resolution of colonic obstruction, decreased tumor size and made a positive effect on the mesorectum. In all cases radical surgeries were performed 48-72 hours after endovascular treatment. The general 5-year survival was 87.5% and the survival without relapse was 75% respectively after such variant of complex treatment. In all cases distant metastases were not detected.