Cationic Rh(II) complexes are able to catalyze the regioselective hydroamination of propargyl ureas in a 6-endo fashion. This transformation permits access to interesting substitution patterns of dihydropyrimidines which have found use as nucleotide exchange factor inhibitors.
Keywords: ARF 6; Rhodium catalysis; dihydropyrimidone; heterocycle; hydroamination.