Abstract
Microglia-driven inflammatory processes are thought to play an important role in ageing and several neurological disorders. Since consumption of a diet rich in polyphenols has been associated with anti-inflammatory and neuroprotective effects, we studied the effects of twenty-five stilbenoids isolated from Milicia excelsa, Morus alba, Gnetum africanum, and Vitis vinifera. These compounds were tested at 5 and 10 µM on BV-2 microglial cells stimulated with bacterial lipopolysaccharide. Ten stilbenoids reduced lipopolysaccharide-induced nitric oxide production at 5 and/or 10 µM. Two tetramers, E-vitisin A and E-vitisin B, were the most effective molecules. Moreover, they attenuated the expression of the inducible NO synthase protein and gene.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / pharmacology*
-
Benzofurans / chemistry
-
Benzofurans / isolation & purification
-
Benzofurans / pharmacology
-
Cell Line
-
Cell Survival / drug effects
-
Gnetum / chemistry*
-
Lipopolysaccharides / pharmacology
-
Microglia / drug effects
-
Microglia / metabolism
-
Moraceae / chemistry*
-
Morus / chemistry*
-
Neuroprotective Agents / chemistry
-
Neuroprotective Agents / pharmacology*
-
Nitric Oxide / metabolism
-
Nitric Oxide Synthase Type II / drug effects
-
Nitric Oxide Synthase Type II / genetics
-
Nitric Oxide Synthase Type II / metabolism
-
Phenols / chemistry
-
Phenols / isolation & purification
-
Phenols / pharmacology
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology
-
Plant Roots / chemistry
-
Plant Stems / chemistry
-
Polyphenols / pharmacology
-
Stilbenes / chemistry
-
Stilbenes / isolation & purification
-
Stilbenes / pharmacology*
-
Vitis / chemistry*
Substances
-
Anti-Inflammatory Agents
-
Benzofurans
-
Lipopolysaccharides
-
Neuroprotective Agents
-
Phenols
-
Plant Extracts
-
Polyphenols
-
Stilbenes
-
malvidin-3-O-glucoside-4 vinyl
-
vitisin A
-
Nitric Oxide
-
NOS2 protein, human
-
Nitric Oxide Synthase Type II