Latanoprost/timolol fixed combination for the treatment of glaucoma

Expert Opin Pharmacother. 2013 Sep;14(13):1815-27. doi: 10.1517/14656566.2013.813482. Epub 2013 Jun 28.

Abstract

Introduction: Glaucoma is a multifactorial optic neuropathy that can lead to progressive and irreversible loss of vision. Today there are > 60 million glaucoma patients worldwide, and this figure is rising due to aging. The aim of glaucoma therapy is to maintain the patient's visual function and quality of life by means of intraocular pressure (IOP) reduction, which currently constitutes the only evidence-based approach.

Areas covered: Briefly discussed are selected, recent evidence on antiglaucoma fixed combinations. Then the efficacy and safety of the latanoprost/timolol fixed combination is comprehensively reviewed.

Expert opinion: The latanoprost/timolol fixed combination can be a helpful stepwise therapeutic option in patients whose IOP is insufficiently controlled with monotherapy options. Future research is needed to better delineate the role and value of this medication in glaucoma therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Antihypertensive Agents / administration & dosage*
  • Antihypertensive Agents / adverse effects
  • Drug Combinations
  • Glaucoma / drug therapy*
  • Humans
  • Intraocular Pressure / drug effects
  • Latanoprost
  • Prostaglandins F, Synthetic / administration & dosage*
  • Prostaglandins F, Synthetic / adverse effects
  • Timolol / administration & dosage*
  • Timolol / adverse effects
  • Treatment Outcome

Substances

  • Antihypertensive Agents
  • Drug Combinations
  • Prostaglandins F, Synthetic
  • Latanoprost
  • Timolol