Abstract
Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known alkaloids (3, 5-11). Alstonisine (9) exhibited antiplasmodial activity against Plasmodium falciparum, with an IC50 of 7.6 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Alstonia / chemistry*
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indole Alkaloids / pharmacology
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Indoles
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Inhibitory Concentration 50
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KB Cells
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oxindoles
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Plant Bark / chemistry
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Plasmodium falciparum / drug effects
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Spiro Compounds
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Thailand
Substances
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Alkaloids
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Antimalarials
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Indole Alkaloids
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Indoles
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Oxindoles
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Spiro Compounds
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alstoniaphylline A
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alstoniaphylline C
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alstonisine