Abstract
Six new triterpene saponins, clematomandshurica saponins F-K (1-6), together with a known compound (7), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis. Compounds 5-7 exhibited antiproliferative effects against PC-3 human prostate cancer cells with GI50 values of 1.29, 1.50, and 0.71 µM, respectively.
Georg Thieme Verlag KG Stuttgart · New York.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Carbon Isotopes / analysis
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival
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China
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Clematis / chemistry*
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Humans
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Hydrolysis
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Magnetic Resonance Spectroscopy
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Medicine, Chinese Traditional
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Molecular Structure
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Plant Roots / chemistry
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Plants, Medicinal
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Rhizome / chemistry
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Saponins / chemistry
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Saponins / isolation & purification
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Saponins / pharmacology*
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Carbon Isotopes
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Saponins
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Triterpenes