Targeting two co-operating cytokines efficiently shapes immune responses

Andreas A Hombach; Hinrich Abken

doi:10.4161/onci.23205

Targeting two co-operating cytokines efficiently shapes immune responses

Oncoimmunology. 2013 Mar 1;2(3):e23205. doi: 10.4161/onci.23205.

Authors

Andreas A Hombach¹, Hinrich Abken

Affiliation

¹ Department I of Internal Medicine; Center for Molecular Medicine Cologne (CMMC); University Hospital Cologne; University of Cologne; Cologne, Germany.

Abstract

For simultaneously mobilizing the adaptive and innate immune system against cancer, we fused interleukin (IL)-2 and IL-12 to generate a dual cytokine moiety that is targeted to neoplastic lesions by an antibody-binding domain. This approach elicits a broader attack of the immune system against cancer than the use of each cytokine alone.

Keywords: Hodgkin's lymphoma; IL-12; IL-2; NK cell; T cell; T helper cell polarization; antibody-cytokine fusion protein; immune therapy.