Separate goals, converging priorities: on the ethics of treatment as prevention

Dev World Bioeth. 2013 Aug;13(2):57-62. doi: 10.1111/dewb.12021. Epub 2013 Jun 25.

Abstract

Recent evidence confirming that the administration of antiretroviral drugs (ARVs) to HIV-infected persons may effectively reduce their risk of transmission has revived the discussion about priority setting in the fight against HIV/AIDS. The fact that the very same drugs can be used both for treatment purposes and for preventive purposes (Treatment as Prevention) has been seen as paradigm-shifting and taken to spark a new controversy: In a context of scarce resources, should the allocation of ARVs be prioritized based on the goal of providing treatment, or on the goal of preventing the spread of the HIV epidemic? Contributions to this discussion tend to assume that treatment and prevention constitute two divergent goals that entail conflicting priorities. We challenge that assumption on the basis of both conceptual and empirical examination. We argue that, as far as the provision of ARVs to HIV-infected persons is concerned, the goals of treatment and prevention do not entail conflicting priorities; to the contrary, they dictate converging strategies for the optimal allocation of ARVs. In light of the current evidence, the concept of Treatment as Prevention can indeed be seen as paradigm-shifting, yet in a novel way: Rather than extending the tension between the goals of treatment and prevention to the level of drug-allocation, it dissolves this tension by providing a rationale for a unified strategy for allocating ARVs.

Keywords: HIV/AIDS; antiretroviral therapy; bioethics; prevention; priority setting; treatment; treatment as prevention.

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy
  • Acquired Immunodeficiency Syndrome / prevention & control
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / therapeutic use*
  • Anti-Retroviral Agents / therapeutic use
  • CD4 Lymphocyte Count
  • Developing Countries
  • Disease Transmission, Infectious / ethics
  • Disease Transmission, Infectious / prevention & control
  • Female
  • Goals*
  • HIV Infections / drug therapy*
  • HIV Infections / prevention & control*
  • HIV Infections / transmission
  • Health Care Rationing / ethics*
  • Health Priorities / ethics*
  • Humans
  • Infectious Disease Transmission, Vertical / ethics
  • Infectious Disease Transmission, Vertical / prevention & control
  • Male
  • Primary Prevention / ethics*
  • Primary Prevention / methods

Substances

  • Anti-HIV Agents
  • Anti-Retroviral Agents