A pool-adjacent-violators type algorithm for non-parametric estimation of current status data with dependent censoring

Lifetime Data Anal. 2014 Jul;20(3):444-58. doi: 10.1007/s10985-013-9274-4. Epub 2013 Jun 22.

Abstract

A likelihood based approach to obtaining non-parametric estimates of the failure time distribution is developed for the copula based model of Wang et al. (Lifetime Data Anal 18:434-445, 2012) for current status data under dependent observation. Maximization of the likelihood involves a generalized pool-adjacent violators algorithm. The estimator coincides with the standard non-parametric maximum likelihood estimate under an independence model. Confidence intervals for the estimator are constructed based on a smoothed bootstrap. It is also shown that the non-parametric failure distribution is only identifiable if the copula linking the observation and failure time distributions is fully-specified. The method is illustrated on a previously analyzed tumorigenicity dataset.

MeSH terms

  • Algorithms*
  • Animals
  • Computer Simulation
  • Confidence Intervals
  • Germ-Free Life
  • Humans
  • Likelihood Functions*
  • Mice
  • Models, Statistical*
  • Neoplasms / etiology