New triterpenes from a Chinese medicine, goreishi

Chem Pharm Bull (Tokyo). 1990 Apr;38(4):942-4. doi: 10.1248/cpb.38.942.

Abstract

Besides serratagenic acid, three new ursane-type triterpenes, named goreishic acids I (1), II (2), and III (3), were isolated from a Chinese medicine, Goreishi (the feces of Trogopterus xanthipes Milne-Edwards). The structures of 1, 2 and 3 were respectively determined as 2 alpha,3 beta-dihydroxyursa-12,18-dien-28-oic acid, 2 alpha,3 beta-dihydroxy-23-norursa-12,18-dien-28-oic acid and 2 alpha,3 beta-dihydroxy-24-norursa-12,18-dien-28-oic acid on the basis of spectroscopic evidence.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / analysis
  • Chemical Phenomena
  • Chemistry
  • Drugs, Chinese Herbal / analysis*
  • Drugs, Chinese Herbal / pharmacology
  • Mice
  • Triterpenes / analysis*
  • Triterpenes / pharmacology
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Triterpenes
  • goreishic acid I
  • goreishic acid II
  • serratagenic acid