Scaffolding proteins: not such innocent bystanders

Curr Biol. 2013 Jun 17;23(12):R515-7. doi: 10.1016/j.cub.2013.05.002.

Abstract

Sequential transfer of information from one enzyme to the next within the confines of a protein kinase scaffold enhances signal transduction. Though frequently considered to be inert organizational elements, two recent reports implicate kinase-scaffolding proteins as active participants in signal relay.

Publication types

  • Comment

MeSH terms

  • Animals
  • Axin Protein / metabolism*
  • Cell Cycle Proteins / metabolism*
  • Deoxyribonucleases / metabolism*
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Low Density Lipoprotein Receptor-Related Protein-6 / metabolism*
  • Mitosis*
  • Phosphoproteins / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Wnt Proteins / metabolism*
  • beta Catenin / metabolism*
  • tRNA Methyltransferases / metabolism*

Substances

  • Axin Protein
  • Cell Cycle Proteins
  • Low Density Lipoprotein Receptor-Related Protein-6
  • Phosphoproteins
  • Saccharomyces cerevisiae Proteins
  • Wnt Proteins
  • beta Catenin
  • tRNA Methyltransferases
  • Protein Serine-Threonine Kinases
  • Deoxyribonucleases
  • GTP-Binding Proteins