Abstract
Glucocorticoids may have dual action on the gastric mucosa: gastroprotective and ulcerogenic. In this article, we review the data which suggested that an initial action of endogenous glucocorticoids, including stress-produced ones as well as exogenous glucocorticoids is gastroprotective and consider possible mechanisms of the conversion of physiological gastroprotective action of glucocorticoid hormones to their pathological ulcerogenic effect.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / adverse effects
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
-
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
-
Gastric Mucosa / cytology*
-
Gastric Mucosa / drug effects*
-
Gastric Mucosa / pathology
-
Glucocorticoids / adverse effects*
-
Glucocorticoids / metabolism*
-
Glucocorticoids / pharmacology
-
Humans
-
Hypothalamo-Hypophyseal System / drug effects
-
Pituitary-Adrenal System / drug effects
-
Stomach Ulcer / chemically induced*
-
Stomach Ulcer / pathology*
-
Stomach Ulcer / physiopathology
-
Stress, Psychological / metabolism
-
Time Factors
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Glucocorticoids