Novel and simple prognostic index for nasal natural killer/T-cell lymphoma

Head Neck. 2014 Apr;36(4):551-6. doi: 10.1002/hed.23322. Epub 2013 Jun 18.

Abstract

Background: Few studies have investigated the prognostic factors for nasal natural killer (NK)/T-cell lymphoma.

Methods: This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T-cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals.

Results: High serum levels of C-reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), and soluble interleukin-2 receptor (sIL-2R; ≥600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease-specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2.

Conclusion: Our NPI is valid for anticipating prognosis of nasal NK/T-cell lymphoma.

Keywords: blood examination; local invasion; nasal NK/T-cell lymphoma; prognosis; prognostic index.

Publication types

  • Multicenter Study

MeSH terms

  • C-Reactive Protein / analysis
  • Female
  • Humans
  • L-Lactate Dehydrogenase / blood
  • Lymphoma, Extranodal NK-T-Cell / blood
  • Lymphoma, Extranodal NK-T-Cell / mortality*
  • Male
  • Middle Aged
  • Nasal Cavity / pathology
  • Neoplasm Invasiveness
  • Nose Neoplasms / blood
  • Nose Neoplasms / mortality*
  • Prognosis
  • Proportional Hazards Models
  • Receptors, Interleukin-2 / blood
  • Retrospective Studies

Substances

  • Receptors, Interleukin-2
  • C-Reactive Protein
  • L-Lactate Dehydrogenase