Abstract
Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine-derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-positive bacteria, such as anthrax, but also shows activity against selected Gram-negative bacteria.
Keywords:
anthrax; antibiotics; bacillus anthracis; natural products; polyketides.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Actinobacteria*
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Anthrax / drug therapy*
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Anthrax / microbiology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Bacillus anthracis / drug effects*
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Geologic Sediments / chemistry
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Geologic Sediments / microbiology*
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Gram-Positive Bacteria / drug effects*
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Microbial Sensitivity Tests
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Molecular Structure
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Polyketides / chemistry
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Polyketides / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
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Water Pollutants, Chemical / chemistry*
Substances
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Anti-Bacterial Agents
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Polyketides
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Water Pollutants, Chemical
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anthracimycin